multiple sclerosis: pathogenesis, symptoms, diagnoses and cell-based therapy

Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy

Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) lesions that can lead to severe physical or cognitive disability as well as neurological defects. Although the etiology and pathogenesis of MS remains unclear, the present documents illustrate that the cause of MS is multifactorial and include genetic predisposition together with environmenta...

P 151: Clinical Trial in Cell Therapy of Multiple Sclerosis

Neuroinflammation is a disorder that causes neurological disease. Neuroinflammation has a significant role in induce of Multiple sclerosis (MS) and one of the situations that must be treated stops the ongoing process of inflammation against the CNS by self-reactive lymphocytes. According to the successful results that were obtained from the pre-clinical phase of cell therapy, many studies were ...

The Effectiveness of Mindfulness-Based Cognitive Therapy in Reducing Psychological Symptoms, Meta-Worry and Thought Fusion of Multiple Sclerosis Patients

Purpose: Multiple sclerosis is a progressive neurological disease and a cause of many disabilities in individuals. Set of symptoms and the chronic nature of this disease, together impair the mental state of the person and cause awidervariety of psychological symptoms worsening the disease. Therefor, this study aimed to evaluate the effectiveness of cognitive therapy based on mindfulness psy...

New directions in multiple sclerosis therapy: matching therapy with pathogenesis.

All currently approved therapies for multiple sclerosis (MS) modulate systemic immune components prior to their entry into the central nervous system (CNS). Available data indicate they lack impact on the progressive phases of disease; the more potent systemic immune-directed agents predispose to development of infectious or neoplastic disorders. Development of new agents that enhance disease s...

mesenchymal stem cell therapy for multiple sclerosis

human mesenchymal stem cell (msc) can be isolated from bone marrow (bm) and differentiated into multiple lineages. these properties make them promising tools in cell and gene therapy. up to now, no definite therapeutic intervention for late stages of multiple sclerosis (ms) has been found. we decided to inject ms patients with autologous expanded msc. five patients participated in this ongoing ...

Multiple sclerosis: insights into molecular pathogenesis and therapy.